Package: NNTbiomarker 0.31
NNTbiomarker: Calculate Design Parameters for Biomarker Validation Studies
Helps a clinical trial team discuss the clinical goals of a well-defined biomarker with a diagnostic, staging, prognostic, or predictive purpose. From this discussion will come a statistical plan for a (non-randomized) validation trial. Both prospective and retrospective trials are supported. In a specific focused discussion, investigators should determine the range of "discomfort" for the NNT, number needed to treat. The meaning of the discomfort range, [NNTlower, NNTupper], is that within this range most physicians would feel discomfort either in treating or withholding treatment. A pair of NNT values bracketing that range, NNTpos and NNTneg, become the targets of the study's design. If the trial can demonstrate that a positive biomarker test yields an NNT less than NNTlower, and that a negative biomarker test yields an NNT less than NNTlower, then the biomarker may be useful for patients. A highlight of the package is visualization of a "contra-Bayes" theorem, which produces criteria for retrospective case-controls studies.
Authors:
NNTbiomarker_0.31.tar.gz
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NNTbiomarker.pdf |NNTbiomarker.html✨
NNTbiomarker/json (API)
# Install 'NNTbiomarker' in R: |
install.packages('NNTbiomarker', repos = c('https://professorbeautiful.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/professorbeautiful/nntbiomarkerhome/issues
Last updated 5 years agofrom:dc7702f3e6. Checks:OK: 1 WARNING: 6. Indexed: yes.
Target | Result | Date |
---|---|---|
Doc / Vignettes | OK | Nov 02 2024 |
R-4.5-win | WARNING | Nov 02 2024 |
R-4.5-linux | WARNING | Nov 02 2024 |
R-4.4-win | WARNING | Nov 02 2024 |
R-4.4-mac | WARNING | Nov 02 2024 |
R-4.3-win | WARNING | Nov 02 2024 |
R-4.3-mac | WARNING | Nov 02 2024 |
Exports:%&%achievable.se.spargminbinom.confintNNT.from.pvNNT.from.sespNNT.to.pvNNT.to.sespNNTintervalsProspectiveNNTintervalsRetrospectivepv.from.NNTpv.from.sesppv.to.NNTpv.to.sespROCplotsrunrunCombinePlotsrunElicitsesp.from.NNTsesp.from.pvsesp.from.pv.feasiblesesp.to.NNTsesp.to.pv
Dependencies:base64encbslibcachemclicommonmarkcrayondigestfastmapfontawesomefsgluehtmltoolshttpuvjquerylibjsonlitelaterlifecyclemagrittrmemoisemimemvbutilspromisesR6rappdirsRcpprlangsassshinysourcetoolsstringistringrvctrswithrxtable
The biomarker crisis
Rendered fromThe_Biomarker_Crisis.Rmd
usingknitr::rmarkdown
on Nov 02 2024.Last update: 2015-05-04
Started: 2015-05-04
debugTools
Rendered fromdebugTools.Rmd
usingknitr::rmarkdown
on Nov 02 2024.Last update: 2015-05-04
Started: 2015-05-03
Using the NNTbiomarker package
Rendered fromUsing_the_NNTbiomarker_package.Rmd
usingknitr::rmarkdown
on Nov 02 2024.Last update: 2015-05-04
Started: 2015-05-03
Readme and manuals
Help Manual
Help page | Topics |
---|---|
Plan a biomarker validation study by focusing on desired clinical actionability. | NNTbiomarker-package NNTbiomarker |
%&% string concatenation | %&% |
argmin Argmin function for a vector. | argmin |
binom.confint | binom.confint |
NNT.to.pv | NNT.to.pv pv.from.NNT |
NNTintervalsRetrospective | NNTintervalsRetrospective |
ROCplots | ROCplots |
run | run |
runCombinePlots | runCombinePlots |
runElicit | runElicit |
setVerboseCatOption | ifVerboseCat setVerboseCatOption |